Contraceptives Jeanine

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Jeanine

Active Ingredients:

Ethinylestradiol + Dienogest

Action mechanism and therapeutic effect of the medication:

Jeanine is a low-dose monophasic progestin-estrogen oral contraceptive. The contraceptive effect of Jeanine is due to a number of complementary mechanisms:

it inhibits the secretion of pituitary gonadotropin-releasing hormone, inhibits the maturation of follicles and ovulation
increases viscosity of cervical mucus, which hinders the penetration of sperm into the uterus
causes endometrial changes that inhibit the implantation of a fertilized egg

Jeanine also helps normalize menstrual cycle by making it more regular, less painful and intense which decreases the risk of iron deficiency anemia.

Dienogest, one of the components of Jeanine, is an active progestogen, nortestosterone derivative with anti-androgenic activity, which is highly similar to the natural female hormone progesterone. Due to dienogest, Janine has a cosmetic effect on skin and hair in women with acne, seborrhea, hirsutism and androgenic alopecia. The study proved the effectiveness of Janine in female patients with acne.

Janine also has a positive effect on the lipid composition of blood, increasing the concentration of HDL.

Medical indications:

Prevention of unwanted pregnancy (hormonal contraception)
Hormonal contraception in women with acne, seborrhea, hirsutism and androgenic alopecia

Jeanine contraindications, precautions and warnings:

Jeanine should not be used if any of the conditions listed below apply:

Venous or arterial thrombosis and thromboembolism
Severe or multiple risk factors for venous or arterial thrombosis (valvular heart lesions, cardiac arrhythmias, including atrial fibrillation, cerebrovascular diseases, disorders of coronary arteries of the heart)
Transient ischemic attack, angina
Migraine with focal neurological symptoms in history
Uncontrolled arterial hypertension
Diabetes mellitus with vascular disorders
Pancreatitis with severe hypertriglyceridemia
Jaundice, hepatic failure, severe liver disease
Benign or malignant liver tumors
Hormone-dependent malignant diseases of genital organs or breasts
Vaginal bleeding of unknown origin
Prolonged immobilization, major surgery, legs surgery, extensive injuries
Pregnancy, breastfeeding
Hypersensitivity to any component of Jeanine

Jeanine must be prescribed with caution:

Obesity, dyslipoproteinemia, hyperlipidemia
Thrombophlebitis of superficial veins
Otosclerosis with deterioration of hearing during the previous pregnancy
Idiopathic jaundice or itching during previous pregnancy
Pregnant women herpes in history
Congenital hyperbilirubinemia
Migraine with aura
Diabetes mellitus
Systemic lupus erythematosus
Crohn's disease and ulcerative colitis
Sickle-cell anemia
Arterial hypertension
Hemolytic uremic syndrome
Cholelithiasis
Porphyria
Sydenham disease

Jeanine side effects:

As with any other drug, side effects can occur with Jeanine. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. Jeanine cause the following side effects:

nervous system and sensory organs: headache, migraine, blurred vision, mood swings, depression, fatigue
digestive system: nausea, vomiting, abdominal pain, diarrhea, cholestatic jaundice
urogenital and endocrine systems: vaginal secretion change, libido changes, pain and tension of the mammary glands, breast enlargement, galactorrhea, fluid retention, weight change
cardio-vascular system: rare - thrombosis and thromboembolism
dermatological and allergic reactions: skin rash, itching, erythema multiforme, chloasma
other: poor tolerance to contact lenses

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Jeanine, please talk to your doctor or pharmacist.

Drug interaction:

Jeanine can potentially interact with the following groups of drugs:

drugs affecting microsomal liver enzymes
barbiturates
anticonvulsants
antituberculosis drugs (eg. Rifampicin)
antifungal drugs (eg. Griseofulvin)
antiretroviral drugs
St John's Wort
antibiotics
hypoglycemic drugs
indirect anticoagulants

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Jeanine which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.