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Digestive System Zelnorm

Zelnorm

Active Ingredients:

• Tegaserod Maleate

Action mechanism and therapeutic effect of the medication:

Stimulates 5-HT4-serotonin receptors in the terminals of afferent neurons in the digestive tract, causing the release of several neurotransmitters. Promotes the peristaltic reflex and basal motor activity of the intestine, thereby normalizing the impaired propulsive activity throughout the gastrointestinal tract. Decreases the number of pulses generated by afferent neurons in response to stretching of the rectum, which may indicate the ability of the drug to reduce the severity of visceral hyperalgesia. Stimulates loosening of the intestine, increases the number of bowel evacuations, reduces the severity of complex symptoms (discomfort / abdominal pain, constipation) relevant to irritable bowel syndrome.

Medical indications: The drug is indicated in:

Irritable bowel syndrome

Zelnorm contraindications, precautions and warnings: The preparation is contraindicated in:

• hypersensitivity
• severe hepatic insufficiency
• pediatric patients
• pregnancy, lactation
• with caution: light or moderate hepatic insufficiency

Zelnorm side effects:

As with any other drug, side effects can occur with tegaserod. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. Zelnorm may cause the following side effects:

• diarrhea, abdominal pain, nausea, flatulence
• headache, dizziness, back pain, flu-like symptoms

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to tegaserod, please talk to your doctor or pharmacist.

Drug interaction: Zelnorm is not known to interact with other drugs. However, we recommend you to talk with your health care provide about drug interactions with tegaserod which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.