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Skin Problems Retin-A

Retin-A

Active Ingredients:

• Tretionon

Action mechanism and therapeutic effect of the medication:

Retin-A belongs to the group of retinoids, structurally related to vitamin A, is a natural metabolite of retinol.

When topically applied, penetrates through cell membranes, forms a cytoplasmic complex, which enters the nucleus of cells. The formed hormone-receptor complex by binding to DNA, prevents the transcription and thereby violates the synthesis of protein. This mechanism underlies a hypopigmented action of tretinoin. Stimulates the mitosis of epidermal cells, increases the amount of elastic fibers in the papillary layer of the skin. Inhibits melanogenesis, increases the growth and differentiation of epithelial cells, inhibits the adhesion of cells forming acne. Inopen blackheads helps leveling the surface of the skin with no signs of inflammation, in closed blackheads helps to open them or transform into papules with a subsequent healing (without scarring), prevents the formation of new acne blemishes. Has antiseborrheic, anti-inflammatory, keratolytic, immune stimulating effect. The therapeutic effect develops in 6-7 weeks of treatment of acne, the maximum effect is usually observed in 8-12 weeks of treatment.

Medical indications:

• confluent acne
• acne vulgaris (including with comedones, papules, pustules)
• cystic nodular elastosis of the skin with comedones (Favre Racouchot disease)

Retin-A contradictions, precautions and warnings:

The drug should not be used in cases of:

• hypersensitivity to any component of the drug
• acute inflammatory (including eczematous) skin lesions (dermatitis, seborrhea, etc.)
• rosacea
• wounds, skin burns, photosensitivity
• pregnancy, breastfeeding, pediatric patients
• should be used with caution in patients with: intracranial hypertension, hepatic and / or renal insufficiency, chronic intoxication, diabetes

Retin-A side effects:

As with any other drug, side effects can occur with Tretinoin. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. Retin-A may cause the following side effects:

• allergic reactions: tingling, hyperemia, burning, swelling
• photosensitivity
• skin hypopigmentation or hyperpigmentation
• peeling and dryness of the skin

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Tretinoin, please talk to your doctor or pharmacist.

Drug interaction:

Retin-A can potentially interact with the following groups of drugs:

• topical antibiotics
• topical acne treatment
• antiseptics
• astringent remedies
• after-shave lotions
• products containing peeling substances, sulfur, ethanol
• cosmetic products for skin and hair containing extract of lemon, having abrasive effect, causing dry skin
• topical alopecia treatment
• drugs increasing photosensitivity
• other retinoids

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Tretinoin which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.